• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】60543

【品名】ethyl 4-fluorobenzoate

【CA登记号】

【 分 子 式 】C9H9FO2

【 分 子 量 】168.1676632

【元素组成】C 64.28% H 5.39% F 11.3% O 19.03%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

The reaction of 4-nitrobenzoic acid ethyl ester (I) with 18FK in DMSO at 150 C gives 4-18Fluorobenzoic acid ethyl ester (II), which is hydrolyzed with NaOH to yield the corresponding free acid (III) Finally, this compound is condensed with 4-acetylpiperazine-1-amine (IV) by means of WSC and HOBT in DMF to afford the target labeled compound. Alternatively, 4-18Fluorobenzoic acid ethyl ester (II) can also be obtained by reaction ethyl 4-aminobenzoate triflate salt (V) with 18FK in DMSO at 120 C.

1 Murakami, Y.; et al.; Synthesis of 18F labelled FK960, a candidate anti-dementia drug, and PET studies in conscious monkeys. J Label Compd Radiopharm 2002, 45, 14, 1219.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 60542 ethyl 4-nitrobenzoate 99-77-4 C9H9NO4 详情 详情
(II) 60543 ethyl 4-fluorobenzoate C9H9FO2 详情 详情
(III) 60544 4-fluorobenzoic acid C7H5FO2 详情 详情
(IV) 17262 1-(4-aminopiperazino)-1-ethanone C6H13N3O 详情 详情
(V) 60545   C11H16O2 详情 详情
Extended Information