(E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-2-propenoic acid -Drug Synthesis Database

【结构式】

【分子编号】60513

【品名】(E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-2-propenoic acid

【CA登记号】

【分子式】C₁₉H₂₀O₇

【分子量】360.3636

【元素组成】C 63.33% H 5.59% O 31.08%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XVIII)

A further synthetic strategy was based on the Perkin condensation between 3,4,5-trimethoxyphenylacetic acid (XVII) and 3-hydroxy-4-methoxybenzaldehyde (XII). Decarboxylation of the resultant phenylcinnamic acid (XVIII) by heating with copper powder in quinoline furnished the desired stilbene, accompanied by only minor amounts of the corresponding E-isomer

参考文献中间体

合成目标

【1】 Gaukroger, K.; Hadfield, J.A.; Hepworth, L.A.; Lawrence, N.J.; McGrown, A.T.; Novel synthesis of cis and trans isomers of combretastatin A-4. J Org Chem 2001, 66, 24, 8135.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	60505	2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol	117048-60-9	C₁₈H₂₀O₅	详情	详情
(XII)	18455	3-hydroxy-4-methoxybenzaldehyde; Isovanillin	621-59-0	C₈H₈O₃	详情	详情
(XVII)	25349	2-(3,4,5-trimethoxyphenyl)acetic acid	937-52-0	C₁₁H₁₄O₅	详情	详情
(XVIII)	60513	(E)-3-(3-hydroxy-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-2-propenoic acid		C₁₉H₂₀O₇	详情	详情

Extended Information