(2E,6E,10E,14E,18E,22E,26E,30E)-1-bromo-3,7,11,15,19,23,27,31,35-nonamethyl-2,6,10,14,18,22,26,30,34-hexatriacontanonaene -Drug Synthesis Database

【结构式】

【分子编号】60504

【品名】(2E,6E,10E,14E,18E,22E,26E,30E)-1-bromo-3,7,11,15,19,23,27,31,35-nonamethyl-2,6,10,14,18,22,26,30,34-hexatriacontanonaene

【CA登记号】

【分子式】C₄₅H₇₃Br

【分子量】693.97862

【元素组成】C 77.88% H 10.6% Br 11.51%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

Reductive alkylation of trans-1,2-cyclohexanediamine (I) with veratraldehyde (II) in the presence of NaBH4 afforded the corresponding bis-(benzylamino)cyclohexane derivative (III). This was then alkylated with solanesyl bromide (IV) in THF to furnish the title compound

参考文献中间体

合成目标

【1】 Inomata, K.; Takahashi, T.; Inoue, H.; Taniuchi, M.; Yamazaki, H.; Suzuki, M.; Takazawa, T.; Kawamura, K.; Oshida, N.; Ikemoto, H.; Kishie, T. (Nisshin Seifun Group Inc.); Isoprene derivs.. EP 0787716; JP 1997268162 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	23788	(1S,2S)-2-aminocyclohexylamine; (1S,2S)-1,2-cyclohexanediamine	21436-03-3	C₆H₁₄N₂	详情	详情
(II)	18304	3,4-Dimethoxybenzaldehyde; Veratraldehyde	120-14-9	C₉H₁₀O₃	详情	详情
(III)	60503	(1R,2R)-N~1~,N~2~-bis(3,4-dimethoxybenzyl)-1,2-cyclohexanediamine; N-(3,4-dimethoxybenzyl)-N-{(1R,2R)-2-[(3,4-dimethoxybenzyl)amino]cyclohexyl}amine		C₂₄H₃₄N₂O₄	详情	详情
(IV)	60504	(2E,6E,10E,14E,18E,22E,26E,30E)-1-bromo-3,7,11,15,19,23,27,31,35-nonamethyl-2,6,10,14,18,22,26,30,34-hexatriacontanonaene		C₄₅H₇₃Br	详情	详情

Extended Information