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【结 构 式】

【分子编号】60462

【品名】1-[(Z)-5-chloro-4-penten-2-ynyl]-2,4(1H,3H)-pyrimidinedione

【CA登记号】

【 分 子 式 】C9H7ClN2O2

【 分 子 量 】210.61956

【元素组成】C 51.32% H 3.35% Cl 16.83% N 13.3% O 15.19%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

Alkylation of uracil (I) with propargyl bromide (II) in the presence of DBU affords the N1-alkylated product (III). Palladium-catalyzed coupling of the terminal alkyne (III) with cis-1,2-dichloroethene (IV) furnishes the chlorovinyl adduct (V). Subsequent alkylation at the N3-position of (V) with propargyl bromide (II) and DBU leads to the open-chain enediyne (VI). This is finally cyclized to the target bicyclic compound in the presence of Pd(PPh3)4, CuI and butylamine.

1 Hakimelahi, G.H.; et al.; A novel approach towards studying non-genotoxic enediynes as potential anticancer therapeutics. Bioorg Med Chem 2002, 10, 5, 1321.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 30921 2,4(1H,3H)-pyrimidinedione; Uracil 66-22-8 C4H4N2O2 详情 详情
(II) 11176 3-Bromopropyne; 3-Bromo-1-propyne 106-96-7 C3H3Br 详情 详情
(III) 60461 1-(2-propynyl)-2,4(1H,3H)-pyrimidinedione C7H6N2O2 详情 详情
(IV) 28793 (Z)-1,2-dichloroethene 156-59-2 C2H2Cl2 详情 详情
(V) 60462 1-[(Z)-5-chloro-4-penten-2-ynyl]-2,4(1H,3H)-pyrimidinedione C9H7ClN2O2 详情 详情
(VI) 60463 1-[(Z)-5-chloro-4-penten-2-ynyl]-3-(2-propynyl)-2,4(1H,3H)-pyrimidinedione C12H9ClN2O2 详情 详情
Extended Information