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【结 构 式】 
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【分子编号】59995 【品名】 【CA登记号】 |
【 分 子 式 】C18H17Br2N3O3S 【 分 子 量 】515.2254 【元素组成】C 41.96% H 3.33% Br 31.02% N 8.16% O 9.32% S 6.22% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The bromination of rosiglitazone (I) with NBS in hot acetic acid gives the dibromo compound (II), which is the hydrogenated with tritium over Pd/BaSO4 in DMF/TEA to yield the target labeled compound.
| 【1】 Kirefu, T.; Landwater, S.W.; Latter, A.J.; Lawrie, K.W.M.; Morecombe, D.J.; Willcocks, K.; Rosiglitazone maleate (BRL 49653-C); the preparation of [14C] and [3H] isotopomers. J Label Compd Radiopharm 2001, 44, 5, 329. |
Extended Information