|
【结 构 式】 
|
【分子编号】59971 【品名】2-[(8S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl acetate 【CA登记号】1250-97-1 |
【 分 子 式 】C23H32O6 【 分 子 量 】404.50348 【元素组成】C 68.29% H 7.97% O 23.73% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The title compound was prepared by dehydration of 11-hydroxyl group of hydrocortisone acetate (I) by means of methanesulfonyl chloride and pyridine in hot DMF. Dehydration of (I) has also been reported by treatment with N,N'-sulfinyldiimidazole, prepared from imidazole and thionyl chloride.
| 【1】 Solyom, S.; et al.; A novel dehydration reaction of steroidal alcohols. J Prakt Chem (Leipzig) 1988, 330, 2, 309. |
| 【2】 Crabbe, P.; Biollaz, M.S. (Syntex (USA) LLC); Process for preparing useful 17alpha-hydroxy-20-keto-21-acyloxy pregnanes. US 3658856 . |
| 【3】 Crabbe, P.; Velarde, E.; Novel process for the preparation of more valuable steroid derivs. and intermediates for the same. DE 2141127 . |
| 【4】 Crabbe, P.; Velarde, E. (Syntex (USA) LLC); Process for preparing 17alpha-hydroxy-20-keto and 17alpha,21-dihydroxy-20-keto pregnanes and derivs. and intermediates thereof. US 3681410 . |
Extended Information