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【结 构 式】 
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【分子编号】59913 【品名】1-[(2R,3R,4R,5R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-hydroxytetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione 【CA登记号】 |
【 分 子 式 】C22H42N2O6Si2 【 分 子 量 】486.75636 【元素组成】C 54.29% H 8.7% N 5.76% O 19.72% Si 11.54% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)Alkylation of the previously reported 2',5'-bis-silylated nucleoside (I) with benzyl bromoacetate (II) in the presence of K2CO3 in acetone provided the N-3-substituted derivative (III). The benzyl ester group was then removed by catalytic hydrogenation over Pd/C to furnish the target carboxylic acid.
| 【1】 Chamorro, C.; Lobatón, E.; Bonache, M.-C.; De Clercq, E.; Balzarini, J.; Velázquez, S.; San-Félix, A.; Camarasa, M.-J.; Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase. Bioorg Med Chem Lett 2001, 11, 23, 3085. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 59913 | 1-[(2R,3R,4R,5R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-hydroxytetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione | C22H42N2O6Si2 | 详情 | 详情 | |
| (II) | 12869 | benzyl 2-bromoacetate | 5437-45-6 | C9H9BrO2 | 详情 | 详情 |
| (III) | 59914 | benzyl 2-[3-[(2R,3R,4R,5R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)-4-hydroxytetrahydro-2-furanyl]-5-methyl-2,6-dioxo-3,6-dihydro-1(2H)-pyrimidinyl]acetate | C31H50N2O8Si2 | 详情 | 详情 |
Extended Information