2,3-dihydro-1-benzofuran-5-sulfonic acid -Drug Synthesis Database

【结构式】

【分子编号】59847

【品名】2,3-dihydro-1-benzofuran-5-sulfonic acid

【CA登记号】

【分子式】C₈H₈O₄S

【分子量】200.21512

【元素组成】C 47.99% H 4.03% O 31.96% S 16.02%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Electrophilic sulfonation of 2,3-dihydrobenzofuran (I) using sulfur trioxide-dimethylformamide complex produced sulfonic acid (II), which was subsequently converted into the sulfonyl chloride (III) by chlorination with SOCl2. Reaction of sulfonyl chloride (III) with a solution of ammonia in cold dichloroethane gave rise to the sulfonamide (IV). This was subsequently condensed with 3,4-dichlophenyl isocyanate (V) to furnish the target sulfonyl urea

参考文献中间体

合成目标

【1】 Tao, E.V.-P.; Miller, W.D. (Eli Lilly and Company); Synthesis of bicyclic aromatic sulfonic acids, sulfonyl chlorides and sulfonamides. EP 0583960 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	14499	2,3-Dihydrobenzofuran; 2,3-dihydro-1-benzofuran	496-16-2	C₈H₈O	详情	详情
(II)	59847	2,3-dihydro-1-benzofuran-5-sulfonic acid		C₈H₈O₄S	详情	详情
(III)	59848	2,3-dihydro-1-benzofuran-5-sulfonyl chloride		C₈H₇ClO₃S	详情	详情
(IV)	59849	2,3-dihydro-1-benzofuran-5-sulfonamide		C₈H₉NO₃S	详情	详情
(V)	34282	1,2-dichloro-4-isocyanatobenzene; 3,4-dichlorophenyl isocyanate	102-36-3	C₇H₃Cl₂NO	详情	详情

Extended Information