1-cyclopropyl-3-{[(difluoroboryl)oxy]carbonyl}-8-(difluoromethoxy)-6-fluoro-7-[(3S)-3-methylpiperazinyl]-4(1H)-quinolinone -Drug Synthesis Database

【结构式】

【分子编号】59824

【品名】1-cyclopropyl-3-{[(difluoroboryl)oxy]carbonyl}-8-(difluoromethoxy)-6-fluoro-7-[(3S)-3-methylpiperazinyl]-4(1H)-quinolinone

【CA登记号】

【分子式】C₁₉H₁₉BF₅N₃O₄

【分子量】459.180696

【元素组成】C 49.7% H 4.17% B 2.35% F 20.69% N 9.15% O 13.94%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIX)

Condensation of fluoroquinolone (XIV) with piperazine (XVIII) afforded the piperazinyl quinolone adduct (XIX). Then, boron chelate cleavage in (XIX) by refluxing in the presence of Et3N, followed by treatment with HCl provided the title compound

参考文献中间体

合成目标

【1】 Iwata, M.; Kimura, T.; Inoue, T.; Fujihara, Y.; Katsube, T. (Sankyo Co., Ltd.; Ube Industries, Ltd.); 4-Oxoquinoline-3-carboxylic acid derivs., their preparation and their use. AU 8938218; EP 0352123; EP 0610958; JP 1990124873; JP 1990231476; JP 1993255183; US 5002947; US 5073556; US 5348961 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(XIV)	59818	1-cyclopropyl-3-{[(difluoroboryl)oxy]carbonyl}-8-(difluoromethoxy)-6,7-difluoro-4(1H)-quinolinone	C₁₄H₈BF₆NO₄	详情	详情
(XVIII)	59823	(2S)-2-methylpiperazine	C₅H₁₂N₂	详情	详情
(XIX)	59824	1-cyclopropyl-3-{[(difluoroboryl)oxy]carbonyl}-8-(difluoromethoxy)-6-fluoro-7-[(3S)-3-methylpiperazinyl]-4(1H)-quinolinone	C₁₉H₁₉BF₅N₃O₄	详情	详情

Extended Information