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【结 构 式】

【分子编号】59820

【品名】ethyl (2S)-2-aminopropanoate

【CA登记号】

【 分 子 式 】C5H11NO2

【 分 子 量 】117.14788

【元素组成】C 51.26% H 9.46% N 11.96% O 27.31%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XV)

The chiral piperazine building block (XVIII) was prepared as follows. L-Alanine ethyl ester (XV) was condensed with formaldehyde and NaCN to give the amino nitrile (XVI). Catalytic hydrogenation of the cyano group of (XVI) with simultaneous intramolecular cyclization furnished the piperazinone (XVII). This was reduced to the target (S)-2-methylpiperazine (XVIII) by means of LiAlH4 (1).

1 Iwata, M.; Kimura, T.; Inoue, T.; Fujihara, Y.; Katsube, T. (Sankyo Co., Ltd.; Ube Industries, Ltd.); 4-Oxoquinoline-3-carboxylic acid derivs., their preparation and their use. AU 8938218; EP 0352123; EP 0610958; JP 1990124873; JP 1990231476; JP 1993255183; US 5002947; US 5073556; US 5348961 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XV) 59820 ethyl (2S)-2-aminopropanoate C5H11NO2 详情 详情
(XVI) 59821 ethyl (2S)-2-[(cyanomethyl)amino]propanoate C7H12N2O2 详情 详情
(XVII) 59822 (3S)-3-methyl-2-piperazinone C5H10N2O 详情 详情
(XVIII) 59823 (2S)-2-methylpiperazine C5H12N2 详情 详情
Extended Information