(2-chloro-5-nitrophenyl)(4-methoxyphenyl)methanone -Drug Synthesis Database

【结构式】

【分子编号】59706

【品名】(2-chloro-5-nitrophenyl)(4-methoxyphenyl)methanone

【CA登记号】

【分子式】C₁₄H₁₀ClNO₄

【分子量】291.69044

【元素组成】C 57.65% H 3.46% Cl 12.15% N 4.8% O 21.94%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Treatment of 2-chloro-5-nitrobenzoic acid (I) with PCl5 provides acid chloride (II), which is then condensed with anisole in the presence of AlCl3 to furnish the benzophenone (III). Alternatively, ketone (III) is prepared by Friedel-Crafts condensation of 2-chloro-5-nitrobenzoic acid (I) with anisole in hot polyphosphoric acid. Reduction of ketone (III) employing triethylsilane and trifluoromethanesulfonic acid gives rise to diphenylmethane derivative (IV)

参考文献中间体

合成目标

【1】 Manning, R.E.; Tremont, S.J.; Glenn, K.C.; Keller, B.T. (Pharmacia Corp.); Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders. WO 0168096 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	10188	2-Chloro-5-nitrobenzoic acid	2516-96-3	C₇H₄ClNO₄	详情	详情
(II)	10189	2-Chloro-5-nitrobenzoyl chloride	25784-91-2	C₇H₃Cl₂NO₃	详情	详情
(III)	59706	(2-chloro-5-nitrophenyl)(4-methoxyphenyl)methanone		C₁₄H₁₀ClNO₄	详情	详情
(IV)	59707	4-(2-chloro-5-nitrobenzyl)phenyl methyl ether; 1-chloro-2-(4-methoxybenzyl)-4-nitrobenzene		C₁₄H₁₂ClNO₃	详情	详情

Extended Information