2-[2-(2-methoxyphenoxy)ethyl]-1H-isoindole-1,3(2H)-dione -Drug Synthesis Database

【结构式】

【分子编号】59617

【品名】2-[2-(2-methoxyphenoxy)ethyl]-1H-isoindole-1,3(2H)-dione

【CA登记号】

【分子式】C₁₇H₁₅NO₄

【分子量】297.31044

【元素组成】C 68.68% H 5.09% N 4.71% O 21.53%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(V)

Guaiacol (I) was alkylated by means of boiling dibromoethane (II) to produce the bromoethyl ether (III). From this, the intermediate amine (VI) was prepared by Gabriel synthesis, via condensation with potassium phthalimide (IV) in hot DMF, followed by hydrazinolysis of the resultant N-substituted phthalimide (V).

参考文献中间体

合成目标

【1】 Lin, T.-H.; Chen, I.-J.; Guaiacoxypropanolamines with alpha/beta-adrenergic blocking activity. EP 1108710; WO 0005209 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	13182	Guaiacol; 2-Methoxyphenol	90-05-1	C₇H₈O₂	详情	详情
(II)	10252	1,2-Dibromoethane; Ethylene dibromide	106-93-4	C₂H₄Br₂	详情	详情
(III)	51402	2-(2-Bromoethoxy)methoxybenzene; 1-Bromo-2-(2-methoxyphenoxy)ethane	4463-59-6	C₉H₁₁BrO₂	详情	详情
(IV)	27890	Potassium phthalimide	1074-82-4	C₈H₄KNO₂	详情	详情
(V)	59617	2-[2-(2-methoxyphenoxy)ethyl]-1H-isoindole-1,3(2H)-dione		C₁₇H₁₅NO₄	详情	详情
(VI)	31105	2-(2-methoxyphenoxy)ethylamine; 2-(2-methoxyphenoxy)-1-ethanamine	1836-62-0	C₉H₁₃NO₂	详情	详情

Extended Information