• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】59588

【品名】1-(2-hydroxyethyl)-2-imidazolidinone

【CA登记号】3699-54-5

【 分 子 式 】C5H10N2O2

【 分 子 量 】130.14668

【元素组成】C 46.14% H 7.74% N 21.52% O 24.59%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XI)

Acid-catalyzed condensation of 4-piperidone hydrate hydrochloride (IX) with indole (IV) produced the tetrahydropyridyl indole (X). This was alkylated with 1-(2-chloroethyl)imidazolinone (XII), (prepared by chlorination of the corresponding hydroxyethyl imidazolinone (XI)) to afford the N-substituted tetrahydropyridine (XIII). The target piperidine derivative was then obtained by catalytic hydrogenation of tetrahydropyridine (XIII).

1 Perregaard, J.K. (H. Lundbeck A/S); Heterocyclic cpds.. AU 8655901; EP 0200322; ES 8707499; JP 1986236764; US 4710500 .
2 Perregaard, J.K.; Costall, B. (H. Lundbeck A/S); Piperidyl-substd. indoles. EP 0533824; JP 1993509080; US 5439922; WO 9200070 .
3 Bech Sommer, M. (H. Lundbeck A/S); Method of manufacturing sertindole. WO 9851685 .
4 Bogeso, K.P.; Hyttel, J.; Sanchez, C.; Arnt, J.; Perregaard, J.; Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles. J Med Chem 1992, 35, 6, 1092.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(IV) 59582 5-chloro-1-(4-fluorophenyl)-1H-indole C14H9ClFN 详情 详情
(IX) 18178 4,4-piperidinediol 73390-11-1 C5H11NO2 详情 详情
(X) 59587 5-chloro-1-(4-fluorophenyl)-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole C19H16ClFN2 详情 详情
(XI) 59588 1-(2-hydroxyethyl)-2-imidazolidinone 3699-54-5 C5H10N2O2 详情 详情
(XII) 21329 1-(2-chloroethyl)-2-imidazolidinone 2387-20-4 C5H9ClN2O 详情 详情
(XIII) 59589 1-{2-[4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-3,6-dihydro-1(2H)-pyridinyl]ethyl}-2-imidazolidinone 106516-54-5 C24H24ClFN4O 详情 详情
Extended Information