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【结 构 式】 
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【分子编号】59556 【品名】(2S)-2-[(butylsulfonyl)amino]-3-(4-hydroxyphenyl)propanoic acid 【CA登记号】 |
【 分 子 式 】C13H19NO5S 【 分 子 量 】301.3636 【元素组成】C 51.81% H 6.35% N 4.65% O 26.55% S 10.64% |
合成路线1
该中间体在本合成路线中的序号：(XXIX)In a variation of this process, L-tyrosine (XXVII) was initially protected as the bis-O-silylated derivative (XXVIII) employing N,O-bis(trimethylsilyl) trifluoroacetamide. Acylation of (XXVIII) with butanesulfonyl chloride (XIV), followed by hydrolysis of the silyl groups, gave rise to N-butanesulfonyl tyrosine (XXIX). The phenolic hydroxyl of (XXIX) was then alkylated by 4-(4-pyridinyl)butyl chloride (XXII) to produce ether (XXVI). Finally, hydrogenation of the pyridine ring furnished the target piperidine derivative, which was isolated as the corresponding hydrochloride salt.
| 【1】 Chung, J.Y.L.; Zhao, D.; Hughes, D.L. (Merck & Co., Inc.); Process for preparing fibrinogen receptor antagonists. WO 9316995 . |
| 【2】 Chung, J.Y.L.; Zhao, D.; Hughes, D.L.; Grabowski, E.E.; A practical synthesis of fibrinogen receptor antagonist MK-383 - Selective functionalization of (S)-tyrosine. Tetrahedron 1993, 49, 26, 5767. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XIV) | 26779 | 1-butanesulfonyl chloride | 2386-60-9 | C4H9ClO2S | 详情 | 详情 |
| (XXII) | 59551 | 4-(4-chlorobutyl)pyridine | C9H12ClN | 详情 | 详情 | |
| (XXVI) | 59554 | (2S)-2-[(butylsulfonyl)amino]-3-{4-[4-(4-pyridinyl)butoxy]phenyl}propanoic acid | C22H30N2O5S | 详情 | 详情 | |
| (XXVII) | 48794 | (S)-(-)-Tyrosine; (S)-2-Amino-3-(4-hydroxyphenyl)propionic acid; 3-(4-Hydroxyphenyl)-L-alanine; L-(-)-Tyrosine; L-3-(4-Hydroxyphenyl)alanine; L-4-Hydroxy-17O-phenylalanine; L-beta-(p-Hydroxyphenyl)alanine; L-Hydroxy Phenyl Alanine; L-tyrosine | 60-18-4 | C9H11NO3 | 详情 | 详情 |
| (XXVIII) | 59555 | trimethylsilyl (2S)-2-amino-3-{4-[(trimethylsilyl)oxy]phenyl}propanoate | C15H27NO3Si2 | 详情 | 详情 | |
| (XXIX) | 59556 | (2S)-2-[(butylsulfonyl)amino]-3-(4-hydroxyphenyl)propanoic acid | C13H19NO5S | 详情 | 详情 |