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【结 构 式】 
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【分子编号】59552 【品名】methyl (2S)-2-[(butylsulfonyl)amino]-3-(4-hydroxyphenyl)propanoate 【CA登记号】 |
【 分 子 式 】C14H21NO5S 【 分 子 量 】315.39048 【元素组成】C 53.32% H 6.71% N 4.44% O 25.36% S 10.17% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XXIV)Tyrosine methyl ester (XXIII) was acylated with butanesulfonyl chloride (XIV) in the presence of pyridine to produce sulfonamide (XXIV). Mitsunobu coupling of pyridinyl butanol (XX) with the phenolic compound (XXIV) furnished ether (XXV). Subsequent hydrolysis of the methyl ester group of (XXV) employing LiOH afforded acid (XXVI). The title piperidine compound was then obtained by catalytic hydrogenation of the pyridine ring of (XXVI) in the presence of Pd/C.
| 【1】 Chung, J.Y.L.; Zhao, D.; Hughes, D.L. (Merck & Co., Inc.); Process for preparing fibrinogen receptor antagonists. US 5312923; WO 9316994 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XIV) | 26779 | 1-butanesulfonyl chloride | 2386-60-9 | C4H9ClO2S | 详情 | 详情 |
| (XX) | 59550 | 4-(4-pyridinyl)-1-butanol | C9H13NO | 详情 | 详情 | |
| (XXIII) | 21431 | methyl (2S)-2-amino-3-(4-hydroxyphenyl)propanoate | 1080-06-4 | C10H13NO3 | 详情 | 详情 |
| (XXIV) | 59552 | methyl (2S)-2-[(butylsulfonyl)amino]-3-(4-hydroxyphenyl)propanoate | C14H21NO5S | 详情 | 详情 | |
| (XXV) | 59553 | methyl (2S)-2-[(butylsulfonyl)amino]-3-{4-[4-(4-pyridinyl)butoxy]phenyl}propanoate | C23H32N2O5S | 详情 | 详情 | |
| (XXVI) | 59554 | (2S)-2-[(butylsulfonyl)amino]-3-{4-[4-(4-pyridinyl)butoxy]phenyl}propanoic acid | C22H30N2O5S | 详情 | 详情 |
Extended Information