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【结 构 式】

【分子编号】59538

【品名】[3-(1-adamantyl)-4-methoxyphenyl](bromo)magnesium

【CA登记号】

【 分 子 式 】C17H21BrMgO

【 分 子 量 】345.56214

【元素组成】C 59.09% H 6.13% Br 23.12% Mg 7.03% O 4.63%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

Friedel-Crafts condensation of 4-bromophenol (I) with 1-adamantanol (II) in the presence of H2SO4 yielded the adamantyl phenol (III). Subsequent alkylation of the sodium phenoxide of (III) with iodomethane produced the methyl ether (IV). The Grignard reagent (V), prepared from aryl bromide (IV), was converted to the organozincate derivative, and then subjected to a nickel-catalyzed cross-coupling with methyl 6-bromo-2-naphthoate (VI) to furnish adduct (VII). The target carboxylic acid was finally obtained by saponification of the methyl ester (VII).

1 Charpentier, B.; et al.; Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes. J Med Chem 1995, 38, 26, 4993.
2 Shroot, B.; Eustache, J.; Bernardon, J.M. (Laboratoires Galderma SA); Benzonaphthalenic acid derivs., process for their preparation and their use in pharmacy and cosmetics. AU 9047961; EP 0199636; US 4717720; US 5098895; US 5183889 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 25313 4-bromophenol 106-41-2 C6H5BrO 详情 详情
(II) 52642 1-Adamantanol; 1-Hydroxyadamantane; Tricyclo[3.3.1.1]decan-1-ol 768-95-6 C10H16O 详情 详情
(III) 59536 2-(1-adamantyl)-4-bromophenol C16H19BrO 详情 详情
(IV) 59537 1-(5-bromo-2-methoxyphenyl)adamantane; 2-(1-adamantyl)-4-bromophenyl methyl ether C17H21BrO 详情 详情
(V) 59538 [3-(1-adamantyl)-4-methoxyphenyl](bromo)magnesium C17H21BrMgO 详情 详情
(VI) 59539 6-Bromo-2-naphthoic acid methyl ester; Methyl 6-bromo-2-naphthoate 33626-98-1 C12H9BrO2 详情 详情
(VII) 59540 methyl 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoate C29H30O3 详情 详情
Extended Information