(Z)-4-[(mesitylsulfonyl)oxy]-2-butenyl 2,4,6-trimethylbenzenesulfonate -Drug Synthesis Database

【结构式】

【分子编号】59444

【品名】(Z)-4-[(mesitylsulfonyl)oxy]-2-butenyl 2,4,6-trimethylbenzenesulfonate

【CA登记号】

【分子式】C₂₂H₂₈O₆S₂

【分子量】452.59272

【元素组成】C 58.38% H 6.24% O 21.21% S 14.17%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VII)

Alternatively, diol (I) was converted to the bis-sulfonate ester (VII) under phase-transfer conditions. Alkylation of the sodium salt of N-ethyl-1,3-propanediamine disulfonamide (VIII) with the bis-mesytilate (VII) produced (VI), which was then deprotected as above.

参考文献中间体

合成目标

【1】 Reddy, V.K.; Valasinas, A.; Sarkar, A.; Basu, H.S.; Marton, L.J.; Frydman, B.; Conformationally restricted analogues of 1N,12N-bisethylspermine: Synthesis and growth inhibitory effects on human tumor cell lines. J Med Chem 1998, 41, 24, 4723.
【2】 Witiak, D.T.; Frydman, B.J.; Marton, L.J.; Reddy, V.K.; Valasinas, A.L. (Wisconsin Alumni Research Foundation); Conformationally restricted polyamines and their use as antineoplastic agents. JP 2002508739; WO 9817624 .
【3】 Witiak, D.T.; Frydman, B.J.; Marton, L.J.; Reddy, V.K.; Valasinas, A.L. (Wisconsin Alumni Research Foundation); Conformationally restricted polyamines. US 5889061 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	36965	(Z)-2-butene-1,4-diol	6117-80-2	C₄H₈O₂	详情	详情
(III)	41158	2,4,6-trimethylbenzenesulfonyl chloride	773-64-8	C₉H₁₁ClO₂S	详情	详情
(VI)	59443	N-{3-[ethyl(mesitylsulfonyl)amino]propyl}-N-{(Z)-4-[{3-[ethyl(mesitylsulfonyl)amino]propyl}(mesitylsulfonyl)amino]-2-butenyl}-2,4,6-trimethylbenzenesulfonamide		C₅₀H₇₂N₄O₈S₄	详情	详情
(VII)	59444	(Z)-4-[(mesitylsulfonyl)oxy]-2-butenyl 2,4,6-trimethylbenzenesulfonate		C₂₂H₂₈O₆S₂	详情	详情
(VIII)	59445	N-ethyl-N-{3-[(mesitylsulfonyl)amino]propyl}-2,4,6-trimethylbenzenesulfonamide		C₂₃H₃₄N₂O₄S₂	详情	详情

Extended Information