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【结 构 式】 
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【分子编号】59437 【品名】 【CA登记号】 |
【 分 子 式 】C23H30BF4IrO2 【 分 子 量 】617.5116128 【元素组成】C 44.74% H 4.9% B 1.75% F 12.31% Ir 31.13% O 5.18% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XXXIVa)In a further procedure, estradiol (I) was complexed with in situ prepared [Cp*Ir(acetone)3][BF4]2 to afford, after deprotonation with Et3N, the dienone-iridium complex (XXXIVa-b) as a mixture of alpha and beta isomers. The major alpha isomer was isolated by fractional crystallization and subsequently treated with sodium methoxide in MeOH at -40 C to furnish selectively the 2-methoxy adduct (XXXV). Subsequent oxidative decomplexation with iodine in acetonitrile provided the target 2-methoxyestradiol.
| 【1】 Le Bras, J.; et al.; Activation and regioselective ortho-functionalization of the A-ring of beta-estradiol promoted by "Cp*Ir": An efficient organometallic procedure for the synthesis of 2-methoxyestradiol. Organometallics 1997, 16, 8, 1765. |
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