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【结 构 式】 
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【分子编号】59419 【品名】(8R,9S,13S,14S,17S)-3,17-bis(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-2-yl formate 【CA登记号】 |
【 分 子 式 】C23H32O6 【 分 子 量 】404.50348 【元素组成】C 68.29% H 7.97% O 23.73% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XVI)A similar synthetic strategy was used starting from the methoxymethyl-protected compound (XV). Baeyer-Villiger oxidation of the aldehyde function in the presence of phosphate buffer produced the formate ester (XVI), which was further hydrolyzed to phenol (XVII) under basic conditions. Methylation of phenol (XVII) with iodomethane employing a phase-transfer catalyst gave the methyl ether (XVIII). The methoxymethyl protecting groups were finally removed by acidic treatment.
| 【1】 Cushman, M.; Wang, Z.; An optimized synthesis of 2-methoxyestradiol, a naturally occurring human metabolite with anticancer activity. Synth Commun 1998, 28, 23, 4431. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XV) | 59418 | (8R,9S,13S,14S,17S)-3,17-bis(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-2-carbaldehyde | C23H32O5 | 详情 | 详情 | |
| (XVI) | 59419 | (8R,9S,13S,14S,17S)-3,17-bis(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-2-yl formate | C23H32O6 | 详情 | 详情 | |
| (XVII) | 59420 | (8R,9S,13S,14S,17S)-3,17-bis(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-2-ol | C22H32O5 | 详情 | 详情 | |
| (XVIII) | 59421 | (8R,9S,13S,14S,17S)-3,17-bis(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-2-yl methyl ether; (8R,9S,13S,14S,17S)-2-methoxy-3,17-bis(methoxymethoxy)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene | C23H34O5 | 详情 | 详情 |
Extended Information