2-[(2-benzoylbenzoyl)(methyl)amino]acetic acid -Drug Synthesis Database

【结构式】

【分子编号】59376

【品名】2-[(2-benzoylbenzoyl)(methyl)amino]acetic acid

【CA登记号】

【分子式】C₁₇H₁₅NO₄

【分子量】297.31044

【元素组成】C 68.68% H 5.09% N 4.71% O 21.53%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

The reaction of 2-benzoylbenzoic acid (I) with refluxing SOCl2 gives the corresponding acyl chloride (II), which is condensed with 2-(methylamino)acetic acid (III) in benzene to yield the N-(2-benzoylbenzoyl)-N-methylglycine (IV). The reduction of (IV) by means of LiAlH4 in refluxing THF affords the diol (V), which is finally cyclized by means of PPA at 80 C to provide the target benzoxazocine.

参考文献中间体

合成目标

【1】 Galiano Ramos, J.A.; Verde Casanova, M.J.; Fernandez Torija, C. (Instituto de Investigacion y Desarrollo Quimico Biologico SA); Process for the preparation of 1-methyl-5-phenyl-aza-4-oxo-6,7-benzocyclooctane. ES 8104800 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	59365	2-benzophenone carboxylic acid; 2-Benzoylbenzoic acid; 2-Carboxybenzophenone; Benzophenone-2-carboxylic acid; O-benzoylbenzoic acid	85-52-9	C₁₄H₁₀O₃	详情	详情
(II)	59366	2-benzoylbenzoyl chloride		C₁₄H₉ClO₂	详情	详情
(III)	10429	N-Methylglycine; Sarcosine; 2-(Methylamino)acetic acid	107-97-1	C₃H₇NO₂	详情	详情
(IV)	59376	2-[(2-benzoylbenzoyl)(methyl)amino]acetic acid		C₁₇H₁₅NO₄	详情	详情
(V)	59375	2-[{2-[hydroxy(phenyl)methyl]benzyl}(methyl)amino]-1-ethanol		C₁₇H₂₁NO₂	详情	详情

Extended Information