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【结 构 式】 
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【分子编号】59351 【品名】N-[(6R,9S,10R,13S,15aS,22S,24aS)-22-[4-(dimethylamino)benzyl]-6-ethyl-17-hydroxy-10,23-dimethyl-18-(4-morpholinylmethyl)-5,8,12,15,21,24-hexaoxo-13-phenyldocosahydro-12H-pyrido[2,1-f]pyrrolo[2,1-l][1,4,7,10,13,16]oxapentaazacyclononadecin-9-yl]-3-hydroxy-2-pyridinecarboxamide 【CA登记号】 |
【 分 子 式 】C50H65N9O11 【 分 子 量 】968.12016 【元素组成】C 62.03% H 6.77% N 13.02% O 18.18% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VII)In an alternative method, Michael addition of morpholine (V) to the unsaturated ketone (I) gave adduct (VI). Subsequent ketone reduction in (VI) with NaBH4 provided the corresponding alcohol (VII) as a diastereomeric mixture. Dehydration of alcohol (VII), upon treatment with diethylaminosulfur trifluoride, then yielded the title compound.
| 【1】 Barriere, J.-C.; Pantel, G.; Bacqué, E.; Doerflinger, G.; Dutruc-Rosset, G. (Aventis Pharma SA); Streptogramin derivs., production thereof and compsns. containing the same. EP 1204675; FR 2796949; US 6541451; WO 0110895 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 41288 | C46H54N8O10 | 详情 | 详情 | ||
| (V) | 10388 | Morpholine | 110-91-8 | C4H9NO | 详情 | 详情 |
| (VI) | 59352 | N-[(6R,9S,10R,13S,15aS,22S,24aS)-22-[4-(dimethylamino)benzyl]-6-ethyl-10,23-dimethyl-18-(4-morpholinylmethyl)-5,8,12,15,17,21,24-heptaoxo-13-phenyldocosahydro-12H-pyrido[2,1-f]pyrrolo[2,1-l][1,4,7,10,13,16]oxapentaazacyclononadecin-9-yl]-3-hydroxy-2-pyridinecarboxamide | C50H63N9O11 | 详情 | 详情 | |
| (VII) | 59351 | N-[(6R,9S,10R,13S,15aS,22S,24aS)-22-[4-(dimethylamino)benzyl]-6-ethyl-17-hydroxy-10,23-dimethyl-18-(4-morpholinylmethyl)-5,8,12,15,21,24-hexaoxo-13-phenyldocosahydro-12H-pyrido[2,1-f]pyrrolo[2,1-l][1,4,7,10,13,16]oxapentaazacyclononadecin-9-yl]-3-hydroxy-2-pyridinecarboxamide | C50H65N9O11 | 详情 | 详情 |
Extended Information