5-amino-N~1~,N~3~-bis(2,3-dihydroxypropyl)isophthalamide -Drug Synthesis Database

【结构式】

【分子编号】59333

【品名】5-amino-N~1~,N~3~-bis(2,3-dihydroxypropyl)isophthalamide

【CA登记号】

【分子式】C₁₄H₂₁N₃O₆

【分子量】327.33736

【元素组成】C 51.37% H 6.47% N 12.84% O 29.33%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

An improved method for the preparation of the iodinated precursor (II) has been reported. Thus, iodination of the amino isophthalamide (I) with iodine monochloride is performed with co-addition of phosphoric acid, to yield a higher purity triiodo derivative (II).

参考文献中间体

合成目标

【1】 Leibner, J.E. (Mallinckrodt Medical Inc.); Improved synthesis of ioversol using phosphoric acid modified co-addition. WO 9535122 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	59333	5-amino-N~1~,N~3~-bis(2,3-dihydroxypropyl)isophthalamide		C₁₄H₂₁N₃O₆	详情	详情
(II)	59316	5-amino-N~1~,N~3~-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide		C₁₄H₁₈I₃N₃O₆	详情	详情

Extended Information