2-(acetyloxy)-1-({[3-amino-5-({[2,3-bis(acetyloxy)propyl]amino}carbonyl)-2,4,6-triiodobenzoyl]amino}methyl)ethyl acetate -Drug Synthesis Database

【结构式】

【分子编号】59322

【品名】2-(acetyloxy)-1-({[3-amino-5-({[2,3-bis(acetyloxy)propyl]amino}carbonyl)-2,4,6-triiodobenzoyl]amino}methyl)ethyl acetate

【CA登记号】

【分子式】C₂₂H₂₆I₃N₃O₁₀

【分子量】873.17607

【元素组成】C 30.26% H 3% I 43.6% N 4.81% O 18.32%

与该中间体有关的原料药合成路线共 2 条

合成路线1 合成路线2

合成路线1

该中间体在本合成路线中的序号：(V)

Chlorination of 5-amino-2,4,6-triiodoisophthalic acid (I) with SOCl2 in EtOAc or toluene affords acid chloride (II). Yields have been improved with the addition of benzyltriethylammonium chloride as a catalyst. Acid chloride (II) is then condensed with 3-amino-1,2-propanediol (III) to produce diamide (IV). Compound (IV) is converted to the tetraacetate ester (V) employing acetic anhydride in pyridine. Subsequent acylation of the amino group of (V) with acetoxyacetyl chloride (VI) gives amide (VII). After saponification of the ester groups of (VII), the resultant hydroxy acetamide (VIII) is alkylated by 2-chloroethanol (IX) to furnish the title compound. Alternatively, amide (VIII) is alkylated by bromoethyl acetate (X), producing (XI). Hexa-ester (XI) is finally hydrolyzed with aqueous sulfuric acid. An improved procedure for this final hydrolysis step uses 1,1,2-trichloroethane as co-solvent.

参考文献中间体

合成目标

【1】 Lin, Y. (Mallinckrodt Medical Inc.); Cpds. suitable for X-ray visualisation methods. EP 0083964; US 4396598 .
【2】 Dunn, T.J.; White, D.H.; Kneller, M.T.; Jones, M.M.; Doran, N.O. III; Bailey, A.R. (Mallinckrodt Medical Inc.); Process for producing ioversol. WO 9727172 .
【3】 Kneller, M.T.; Bailey, A.R.; Sathe, S.S.; Spears, A.T.; Wisneski, R.C. (Mallinckrodt Medical Inc.); Improved synthesis of ioversol. WO 9323365 .
【4】 Villa, M.; Castaldi, G.; Pozzoli, C.; Russo, L. (Zambon Group SpA); Process for the preparation of 5-amino-2,4,6-triiodoisophthalic acid dichloride by chlorination with thionyl chloride in the presence of a catalyst. WO 9636590 .
【5】 Lin, Y.; Dean, R.T.; Kneller, M.; Wallace, R.A.; McCarthy, W.Z.; White, D.H. (Mallinckrodt Medical Inc.); Process for production of ioversol. WO 9111431 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	22006	5-amino-2,4,6-triiodoisophthalic acid	35453-19-1	C₈H₄I₃NO₄	详情	详情
(II)	31194	5-amino-2,4,6-triiodoisophthaloyl dichloride	37441-29-5	C₈H₂Cl₂I₃NO₂	详情	详情
(III)	12979	3-Amino-1,2-propanediol；3-aminopropane-1,2-diol	616-30-8	C₃H₉NO₂	详情	详情
(IV)	59316	5-amino-N~1~,N~3~-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide		C₁₄H₁₈I₃N₃O₆	详情	详情
(V)	59322	2-(acetyloxy)-1-({[3-amino-5-({[2,3-bis(acetyloxy)propyl]amino}carbonyl)-2,4,6-triiodobenzoyl]amino}methyl)ethyl acetate		C₂₂H₂₆I₃N₃O₁₀	详情	详情
(VI)	10456	Acetoxiacetil chloride; 2-chloro-2-oxoethyl acetate	13831-31-7	C₄H₅ClO₃	详情	详情
(VII)	59323	2-(acetyloxy)-1-({[3-{[2-(acetyloxy)acetyl]amino}-5-({[2,3-bis(acetyloxy)propyl]amino}carbonyl)-2,4,6-triiodobenzoyl]amino}methyl)ethyl acetate		C₂₆H₃₀I₃N₃O₁₃	详情	详情
(VIII)	59324	N~1~,N~3~-bis(2,3-dihydroxypropyl)-5-(glycoloylamino)-2,4,6-triiodoisophthalamide		C₁₆H₂₀I₃N₃O₈	详情	详情
(IX)	33463	2-bromoethyl acetate	927-68-4	C₄H₇BrO₂	详情	详情
(X)	10384	2-Chloro-1-ethanol; Ethylene chlorohydrin	107-07-3	C₂H₅ClO	详情	详情
(XI)	59325	2-[[2-(acetyloxy)acetyl]-3,5-bis({[2,3-bis(acetyloxy)propyl]amino}carbonyl)-2,4,6-triiodoanilino]ethyl acetate		C₃₀H₃₆I₃N₃O₁₅	详情	详情

合成路线2

该中间体在本合成路线中的序号：(I)

In an alternative procedure, the intermediate amino tetraacetate (I) is acylated by chloroacetyl chloride (II), yielding chloroacetamide (III). The amide N is then alkylated with bromoethyl acetate (IV) to produce (V). Simultaneous hydrolysis of the acetate esters and the chloro group in aqueous sulfuric acid furnishes the title compound.

参考文献中间体

合成目标

【1】 McCarthy, W.Z.; Kneller, M.T.; Lin, Y.; White, D.H. (Mallinckrodt Medical Inc.); Synthesis of ioversol using chloroacetyl chloride. WO 9301840 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	59322	2-(acetyloxy)-1-({[3-amino-5-({[2,3-bis(acetyloxy)propyl]amino}carbonyl)-2,4,6-triiodobenzoyl]amino}methyl)ethyl acetate		C₂₂H₂₆I₃N₃O₁₀	详情	详情
(II)	11296	2-Chloroacetyl chloride; Chloroacetic chloride	79-04-9	C₂H₂Cl₂O	详情	详情
(III)	59328	2-(acetyloxy)-1-[({3-({[2,3-bis(acetyloxy)propyl]amino}carbonyl)-5-[(2-chloroacetyl)amino]-2,4,6-triiodobenzoyl}amino)methyl]ethyl acetate		C₂₄H₂₇ClI₃N₃O₁₁	详情	详情
(IV)	33463	2-bromoethyl acetate	927-68-4	C₄H₇BrO₂	详情	详情
(V)	59329	2-(acetyloxy)-1-({[3-[[2-(acetyloxy)ethyl](2-chloroacetyl)amino]-5-({[2,3-bis(acetyloxy)propyl]amino}carbonyl)-2,4,6-triiodobenzoyl]amino}methyl)ethyl acetate		C₂₈H₃₃ClI₃N₃O₁₃	详情	详情

Extended Information