• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】62794

【品名】1-{[(dimethylamino)carbonyl]oxy}-3-methylpyridinium chloride

【CA登记号】

【 分 子 式 】C9H13ClN2O2

【 分 子 量 】216.6672

【元素组成】C 49.89% H 6.05% Cl 16.36% N 12.93% O 14.77%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

3-Picoline (I) is oxidized to the corresponding N-oxide (II) by means of peracetic acid. Condensation of (II) with dimethylcarbamoyl chloride furnishes carbamate (III), which is then reacted with cyanotrimethylsilane, producing 2-cyano-5-methylpyridine (IV). Subsequent addition of methylmagnesium iodide to the cyanopyridine (IV) gives rise to the pyridyl ketone (V).

1 Easmon, J.; Fürtinger, S.; Lackner, G. ; Magreiter, E.; Hofmann, J.; Heinisch, G.; Puerstinger, G.; Hydrazones derived from monosubstitued 2-acetylpyridines and 2-hydrazino-1-methylbenzimidazole: Synthesis and biological studies. Eur J Cancer 2002, 38, Suppl. 7.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 62792 3-Methylpyridine; 3-Picoline 108-99-6 C6H7N 详情 详情
(II) 62793 3-Methyl-1-pyridiniumolate; 3-Picoline N-oxide 1003-73-2 C6H7NO 详情 详情
(III) 62794 1-{[(dimethylamino)carbonyl]oxy}-3-methylpyridinium chloride C9H13ClN2O2 详情 详情
(IV) 38502 5-methyl-2-pyridinecarbonitrile C7H6N2 详情 详情
(V) 62795 1-(5-methyl-2-pyridinyl)-1-ethanone C8H9NO 详情 详情
Extended Information