4-((5R,5aR,8aR,9S)-9-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy}-6-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxyphenyl (2,2-dimethyl-1,3-dioxolan-4-yl)methyl car -Drug Synthesis Database

【结构式】

【分子编号】62776

【品名】4-((5R,5aR,8aR,9S)-9-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy}-6-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxyphenyl (2,2-dimethyl-1,3-dioxolan-4-yl)methyl car

【CA登记号】

【分子式】C₃₆H₄₂O₁₇

【分子量】746.71928

【元素组成】C 57.91% H 5.67% O 36.42%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Condensation of etoposide (I) with 2,2-dimethyl-1,3-dioxolan-4-ylmethyl chloroformate (II) provides the carbonate ester (III). Then, acidic hydrolysis of the acetonide group of (III) leads to the target compound.

参考文献中间体

合成目标

【1】 Wrasidlo, W.; et al.; Synthesis, hydrolytic activation and cytotoxicity of etoposide prodrugs. Bioorg Med Chem Lett 2002, 12, 4, 557.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	13041	Etoposide; (5R,5aR,8aR,9S)-9-[[(2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one	33419-42-0	C₂₉H₃₂O₁₃	详情	详情
(II)	56226	4-{[(chlorocarbonyl)oxy]methyl}-2,2-dimethyl-1,3-dioxolane		C₇H₁₁ClO₄	详情	详情
(III)	62776	4-((5R,5aR,8aR,9S)-9-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy}-6-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxyphenyl (2,2-dimethyl-1,3-dioxolan-4-yl)methyl car		C₃₆H₄₂O₁₇	详情	详情

Extended Information