5-bromo-2-[{[4-(2-butynyloxy)phenyl]sulfonyl}(methyl)amino]-3-[(4-methyl-1-piperazinyl)methyl]benzoyl chloride -Drug Synthesis Database

【结构式】

【分子编号】60455

【品名】5-bromo-2-[{[4-(2-butynyloxy)phenyl]sulfonyl}(methyl)amino]-3-[(4-methyl-1-piperazinyl)methyl]benzoyl chloride

【CA登记号】

【分子式】C₂₄H₂₇BrClN₃O₄S

【分子量】568.9189

【元素组成】C 50.67% H 4.78% Br 14.04% Cl 6.23% N 7.39% O 11.25% S 5.64%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XII)

Acid (XI) is then activated as the corresponding acid chloride (XII) upon treatment with oxalyl chloride in the presence of DMF. Finally, reaction of acid chloride (XII) with hydroxylamine leads to the title hydroxamic acid.

参考文献中间体

合成目标

【1】 Levin, J.I.; Chen, J.M.; Du, M.T.; Nelson, F.C.; Killar, L.M.; Skala, S.; Sung, A.; Jin, G.; Cowling, R.; Barone, D.; March, C.J.; Mohler, K.M.; Black, R.A.; Skotnicki, J.S.; Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 2: SAR of the acetylenic P1' group. Bioorg Med Chem Lett 2002, 12, 8, 1199.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(XI)	60454	5-bromo-2-[{[4-(2-butynyloxy)phenyl]sulfonyl}(methyl)amino]-3-[(4-methyl-1-piperazinyl)methyl]benzoic acid		C₂₄H₂₈BrN₃O₅S	详情	详情
(XII)	60455	5-bromo-2-[{[4-(2-butynyloxy)phenyl]sulfonyl}(methyl)amino]-3-[(4-methyl-1-piperazinyl)methyl]benzoyl chloride		C₂₄H₂₇BrClN₃O₄S	详情	详情

Extended Information