3-[(3S)-1-benzoyl-3-(3,4-dichlorophenyl)piperidinyl]propanal -Drug Synthesis Database

【结构式】

【分子编号】60037

【品名】3-[(3S)-1-benzoyl-3-(3,4-dichlorophenyl)piperidinyl]propanal

【CA登记号】

【分子式】C₂₁H₂₁Cl₂NO₂

【分子量】390.30868

【元素组成】C 64.62% H 5.42% Cl 18.17% N 3.59% O 8.2%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VI)

The previously reported (hydroxypropyl)piperidine derivative (V) is subjected to Swern oxidation to produce aldehyde (VI). Then, reductive amination of (VI) with piperidine (IV) in the presence of NaBH3CN affords the target compound

参考文献中间体

合成目标

【1】 Proietto, V.; Van Broeck, D.; Edmonds-Alt, X.; Aulombard, A. (Sanofi-Synthelabo); Ureidopiperidine derivs. as selective human NK3 receptor antagonists. EP 1119552; JP 2002527423; US 6465489; WO 0021931 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(IV)	54996	N,N-dimethyl-N'-(4-phenyl-4-piperidinyl)urea	C₁₄H₂₁N₃O	详情	详情
(V)	29467	[(3S)-3-(3,4-dichlorophenyl)-3-(3-hydroxypropyl)piperidinyl](phenyl)methanone	C₂₁H₂₃Cl₂NO₂	详情	详情
(VI)	60037	3-[(3S)-1-benzoyl-3-(3,4-dichlorophenyl)piperidinyl]propanal	C₂₁H₂₁Cl₂NO₂	详情	详情

Extended Information