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【结 构 式】 
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【分子编号】60027 【品名】lithium chloride 2-[4-[(1R,2S)-2,3-dihydroxy-1-(hydroxymethyl)propyl]-7,10-bis(2-hydroxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetic acid 【CA登记号】 |
【 分 子 式 】C18H34ClLiN4O9 【 分 子 量 】492.88322 【元素组成】C 43.86% H 6.95% Cl 7.19% Li 1.41% N 11.37% O 29.21% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VII)In a similar procedure, condensation of (I) with epoxide (II) in isopropanol in the presence of LiCl furnished the corresponding adduct as a complex with LiCl (VI) (2). Condensation of (VI) with chloroacetic acid, followed by acidic hydrolysis provided the lithium complex (VII). Finally, treatment of (VII) with Gd2O3 and HCl afforded the title gadolinium compound
| 【1】 Blaszkiewicz, P.; Platzek, J.; Hoffmann, H.; Petrov, O. (Schering AG); Lithium complexes of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane, production and use thereof. DE 10064467; WO 0248119 . |
| 【2】 Blaszkiewicz, P.; Petrov, O. (Schering AG); Production of mono and 1,7-bis-N-hydroxyalkyl-cyclene and lithium salt complexes. DE 19724186; US 5994536; WO 9855467 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14855 | 1,4,7,10-tetraazacyclododecane; Cyclen | 294-90-6 | C8H20N4 | 详情 | 详情 |
| (II) | 60022 | 4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane | C7H12O3 | 详情 | 详情 | |
| (VI) | 60026 | lithium chloride (5S,6R)-2,2-dimethyl-6-(1,4,7,10-tetraazacyclododecan-1-yl)-1,3-dioxepan-5-ol | C15H32ClLiN4O3 | 详情 | 详情 | |
| (VII) | 60027 | lithium chloride 2-[4-[(1R,2S)-2,3-dihydroxy-1-(hydroxymethyl)propyl]-7,10-bis(2-hydroxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetic acid | C18H34ClLiN4O9 | 详情 | 详情 |
Extended Information