2-[4-[(1R,2S)-2,3-dihydroxy-1-(hydroxymethyl)propyl]-7,10-bis(2-hydroxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetic acid -Drug Synthesis Database

【结构式】

【分子编号】60025

【品名】2-[4-[(1R,2S)-2,3-dihydroxy-1-(hydroxymethyl)propyl]-7,10-bis(2-hydroxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetic acid

【CA登记号】

【分子式】C₁₈H₃₄N₄O₉

【分子量】450.48952

【元素组成】C 47.99% H 7.61% N 12.44% O 31.96%

与该中间体有关的原料药合成路线共 3 条

合成路线1 合成路线2 合成路线3

合成路线1

该中间体在本合成路线中的序号：(V)

1,4,7,10-Tetraazacyclododecane (I) was condensed with 2,3-epoxy-1,4-butanediol acetonide (II) in boiling n-butanol to afford adduct (III). Subsequent acetonide (III) hydrolysis in the presence of HCl led to triol (IV). Alkylation of (IV) with chloroacetic acid furnished the tetraaminotricarboxylic acid (V). Alternatively, compound (V) was prepared by alkylation of (III) with chloroacetic acid, followed by acidic ketal hydrolysis. The title gadolinium complex was finally prepared by treatment of the cyclic tetraamine (V) with gadolinium oxide

参考文献中间体

合成目标

【1】 Gries, H.; Nickisch, K.; Platzek, J.; Börner, H.; Tilstam, U. (Schering AG); Process for producing N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecane derivs. and their metal complexes. DE 4218744; WO 9324469 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	14855	1,4,7,10-tetraazacyclododecane; Cyclen	294-90-6	C₈H₂₀N₄	详情	详情
(II)	60022	4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane		C₇H₁₂O₃	详情	详情
(III)	60023	(5S,6R)-2,2-dimethyl-6-(1,4,7,10-tetraazacyclododecan-1-yl)-1,3-dioxepan-5-ol		C₁₅H₃₂N₄O₃	详情	详情
(IV)	60024	(2S,3R)-3-(1,4,7,10-tetraazacyclododecan-1-yl)-1,2,4-butanetriol		C₁₂H₂₈N₄O₃	详情	详情
(V)	60025	2-[4-[(1R,2S)-2,3-dihydroxy-1-(hydroxymethyl)propyl]-7,10-bis(2-hydroxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetic acid		C₁₈H₃₄N₄O₉	详情	详情

合成路线2

该中间体在本合成路线中的序号：(V)

Alternatively, the protected tetraamine (VIII) was condensed with epoxide (II) to afford (XII), which was further hydrolyzed to the mono-substituted tetraazacyclododecane (III) under basic conditions. Alkylation of (III) with chloracetic acid, followed by acidic ketal hydrolysis furnished the precursor (V), which was finally complexed with gadolinium oxide as above

参考文献中间体

合成目标

【1】 Gries, H.; Platzek, J. (Schering AG); Process for the production of metal complexes of N-beta-hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecane and derivs. thereof. DE 4237943; EP 0596586 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(II)	60022	4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]octane		C₇H₁₂O₃	详情	详情
(III)	60023	(5S,6R)-2,2-dimethyl-6-(1,4,7,10-tetraazacyclododecan-1-yl)-1,3-dioxepan-5-ol		C₁₅H₃₂N₄O₃	详情	详情
(V)	60025	2-[4-[(1R,2S)-2,3-dihydroxy-1-(hydroxymethyl)propyl]-7,10-bis(2-hydroxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetic acid		C₁₈H₃₄N₄O₉	详情	详情
(VIII)	14855	1,4,7,10-tetraazacyclododecane; Cyclen	294-90-6	C₈H₂₀N₄	详情	详情
(XII)	60028	octahydro-5H-2a,4a,7,9a-tetraazacycloocta[cd]pentalene		C₉H₁₈N₄	详情	详情

合成路线3

该中间体在本合成路线中的序号：(V)

In a related method for obtaining the precursor (V), epoxide (II) was condensed with the tosyl-protected tetraamine (XIII) in an autoclave at 170 C to give (XIV). The N-tosyl groups of (XIV) were then removed by treatment with lithium metal in liquid ammonia, yielding intermediate (III), which was then subjected to alkylation with bromoacetic acid, followed by acid hydrolysis

参考文献中间体

合成目标

【1】 Platzek, J.; Gries, H.; Weinmann, H.-J.; Schuhmann-Giampieri, G.; Press, W.-R. (Schering AG); 1,4,7,10-Tetraazacyclododecane-butyl-triols, process for their preparation, and pharmaceutical agents containing these cpds.. DE 4009119; EP 0448191; US 2002176823; US 6399043 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(A)	23660	2-Bromoacetic acid	79-08-3	C₂H₃BrO₂	详情	详情
(II)	30022	1-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-propen-1-ol		C₁₅H₂₀O₃	详情	详情
(III)	60023	(5S,6R)-2,2-dimethyl-6-(1,4,7,10-tetraazacyclododecan-1-yl)-1,3-dioxepan-5-ol		C₁₅H₃₂N₄O₃	详情	详情
(V)	60025	2-[4-[(1R,2S)-2,3-dihydroxy-1-(hydroxymethyl)propyl]-7,10-bis(2-hydroxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetic acid		C₁₈H₃₄N₄O₉	详情	详情
(XIII)	60032	1,4,7-tris[(4-methylphenyl)sulfonyl]-1,4,7,10-tetraazacyclododecane		C₂₉H₃₈N₄O₆S₃	详情	详情
(XIV)	60033	(5S,6R)-2,2-dimethyl-6-{4,7,10-tris[(4-methylphenyl)sulfonyl]-1,4,7,10-tetraazacyclododecan-1-yl}-1,3-dioxepan-5-ol		C₃₆H₅₀N₄O₉S₃	详情	详情

Extended Information