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【结 构 式】 
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【分子编号】59240 【品名】2-fluoro-5-methylbenzenesulfonic acid 【CA登记号】 |
【 分 子 式 】C7H7FO3S 【 分 子 量 】190.1951832 【元素组成】C 44.21% H 3.71% F 9.99% O 25.24% S 16.86% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The title compound was obtained by condensation between 2-fluoro-5-methylbenzenesulfonic acid (I) and piperazine (II) in the presence of copper powder and cuprous iodide in a sealed tube at 160 C. It was converted to the more stable monohydrate form by suspension of the anhydrous crystals in cold water.
| 【1】 Okushima, H.; Narimatsu, A.; Kobayashi, M.; Satoh, N.; Morita, M. (Mitsubishi Chemical Corp.); Aminobenzenesulfonic acid deriv.. EP 0390654; JP 1991007263; US 5053409 . |
| 【2】 Yamazaki, C.; Sato, T.; Nagano, T. (Mitsubishi Chemical Corp.); Monohydrates of aminobenzenesulfonic acid derivs. and method for preparation thereof. EP 0779283; JP 2001316381; US 5990113; US 6245767 . |
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