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【结 构 式】 
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【分子编号】59239 【品名】1-methoxy-4-(trifluoromethoxy)benzene; 4-methoxyphenyl trifluoromethyl ether 【CA登记号】 |
【 分 子 式 】C8H7F3O2 【 分 子 量 】192.1375896 【元素组成】C 50.01% H 3.67% F 29.66% O 16.65% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IX)The precursor 2-methoxy-5-trifluoromethoxybenzaldehyde (III) was prepared as follows. Alkylation of 4-(trifluoromethoxy)phenol (VIII) by means of iodomethane and K2CO3 or dimethyl carbonate and DMAP furnished 4-(trifluoromethoxy)anisole (IX). Formylation of (IX) to the target aldehyde (III) was achieved by treatment with dichloromethyl methyl ether and TiCl4 or with hexamethylenetetraamine and trifluoroacetic acid.
| 【1】 Lowe, J.A. III; Rosen, T.J. (Pfizer Inc.); Fluoroalkoxybenzylamino derivs. of nitrogen containing heterocycles. EP 0589924; JP 1994506473; WO 9300331 . |
| 【2】 Snyder, W.M.; Godek, D.M.; Stewart, A.M. (Pfizer Inc.); Formylation process for aromatic aldehydes. WO 9424081 . |
Extended Information