【结 构 式】 |
【分子编号】59230 【品名】(1R)-3-(1-naphthyloxy)-1-phenyl-1-propanol 【CA登记号】 |
【 分 子 式 】C19H18O2 【 分 子 量 】278.35072 【元素组成】C 81.99% H 6.52% O 11.5% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(XIX)The synthesis of the [11C]-labeled compound was also reported. Selective tosylation of the primary hydroxyl of (R)-1-phenyl-1,3-propanediol (XVI) provided (XVII). From this, naphthyl ether (XIX) was prepared by Williamson's synthesis with the sodium alkoxide of 1-naphthol (XVIII). The remaining hydroxyl group of (XIX) was then converted to mesylate (XX) upon treatment with methanesulfonyl chloride and DMAP. Subsequent displacement with methylamine in a sealed vessel afforded the secondary amine (XXI). This was finally alkylated with 11CH3I to yield the target 11C-labeled compound.
【1】 Livni, E.; et al.; Synthesis of [11C]dapoxetine.HCl, a serotonin re-uptake inhibitor: biodistribution in rat and preliminary PET imaging in the monkey. Nucl Med Biol 1994, 21, 4, 669. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(XVI) | 59233 | (R)-(+)-1-phenyl-1,3-propanediol; (R)-1-Phenyl-1,3-propanediol | 103548-16-9 | C9H12O2 | 详情 | 详情 |
(XVII) | 59234 | (3R)-3-hydroxy-3-phenylpropyl 4-methylbenzenesulfonate | C16H18O4S | 详情 | 详情 | |
(XVIII) | 22935 | alpha-naphthol; 1-naphthol | 90-15-3 | C10H8O | 详情 | 详情 |
(XIX) | 59230 | (1R)-3-(1-naphthyloxy)-1-phenyl-1-propanol | C19H18O2 | 详情 | 详情 | |
(XX) | 59231 | (1R)-3-(1-naphthyloxy)-1-phenylpropyl methanesulfonate | C20H20O4S | 详情 | 详情 | |
(XXI) | 59232 | N-methyl-N-[(1S)-3-(1-naphthyloxy)-1-phenylpropyl]amine; (1S)-N-methyl-3-(1-naphthyloxy)-1-phenyl-1-propanamine | C20H21NO | 详情 | 详情 |
Extended Information