2-(decyloxy)-3-(dodecylsulfanyl)propyl dihydrogen phosphate -Drug Synthesis Database

【结构式】

【分子编号】59215

【品名】2-(decyloxy)-3-(dodecylsulfanyl)propyl dihydrogen phosphate

【CA登记号】

【分子式】C₂₅H₅₃O₅PS

【分子量】496.732582

【元素组成】C 60.45% H 10.75% O 16.1% P 6.24% S 6.46%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(V)

In a further procedure, the monophosphate ester of 3-dodecylmercapto-2-decyloxy-1-propanol (V) was directly condensed with AZT employing DCC as the coupling reagent. A related method involved previous activation of (V) as the mixed anhydride with benzenesulfonyl chloride or triisopropylbenzenesulfonyl chloride in the presence of pyridine.

参考文献中间体

合成目标

【1】 Zilch, H.; Leinert, H.; Mertens, A.; Herrmann, D. (Roche Diagnostics GmbH); New phospholipid derivs. of nucleosides, their preparation and their use as antiviral drugs. DE 4026265; EP 0545966; JP 1994500546; WO 9203462 .
【2】 Zilch, H.; Kiegel, E. (Boehringer Ingelheim GmbH); Method of preparing unsymmetrical phosphoric acid diesters. WO 9520596 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(III)	25317	1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione	101703-35-9	C₁₀H₁₃N₅O₄	详情	详情
(V)	59215	2-(decyloxy)-3-(dodecylsulfanyl)propyl dihydrogen phosphate		C₂₅H₅₃O₅PS	详情	详情

Extended Information