【结 构 式】 |
【分子编号】59136 【品名】3-Ethoxypropionic acid; o-Ethoxypropionic acid 【CA登记号】4324-38-3 |
【 分 子 式 】C5H10O3 【 分 子 量 】118.1326 【元素组成】C 50.84% H 8.53% O 40.63% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(IV)Ketalization of chartreusin (I) with benzaldehyde (II) using p-toluenesulfonic acid in the presence of molecular sieves, yielded the corresponding 3',4'-O-benzylidene derivative as a mixture of endo- and exo-isomers, which were separated by column chromatography. The required exo-isomer (III) was then esterified with 3-ethoxypropionic acid (IV) by means of DCC, producing the title ester.
【1】 Kon, K.; et al.; Synthesis and cytostatic activity of the antitumor antibiotic chartreusin derivatives. J Antibiot 1990, 43, 4, 372. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 59134 | 10-[((2S,3R,4S,5R,6R)-3-{[(2R,3R,4S,5R,6R)-3,5-dihydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-4,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy]-6-hydroxy-1-methylbenzo[h]chromeno[5,4,3-cde]chromene-5,12-dione | C32H32O14 | 详情 | 详情 | |
(II) | 10498 | Benzaldehyde;Benzoic aldehyde;Phenylmethanal | 100-52-7 | C7H6O | 详情 | 详情 |
(III) | 59135 | 10-[((2S,3aR,4R,6S,7R,7aS)-7-{[(2R,3R,4S,5R,6R)-3,5-dihydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-4-methyl-2-phenyltetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-6-yl)oxy]-6-hydroxy-1-methylbenzo[h]chromeno[5,4,3-cde]chromene-5,12-dione | C39H36O14 | 详情 | 详情 | |
(IV) | 59136 | 3-Ethoxypropionic acid; o-Ethoxypropionic acid | 4324-38-3 | C5H10O3 | 详情 | 详情 |
Extended Information