1-[4-(trifluoromethyl)-2-pyridinyl]piperazine -Drug Synthesis Database

【结构式】

【分子编号】59112

【品名】1-[4-(trifluoromethyl)-2-pyridinyl]piperazine

【CA登记号】

【分子式】C₁₀H₁₂F₃N₃

【分子量】231.2207096

【元素组成】C 51.95% H 5.23% F 24.65% N 18.17%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

Alkylation of 2-pyrrolidinone (I) with 1,4-dibromobutane (II) in the presence of KOH and tetraethylammonium bromide gave the N-(4-bromobutyl)pyrrolidinone (III). This was condensed with 1-[4-(trifluoromethyl)-2-pyridinyl]piperazine (IV) in the presence of Na2CO3 to produce the target disubstituted piperazine, which was then converted to the corresponding fumarate salt.

参考文献中间体

合成目标

【1】 Carlier, P.; Combourieu, M.; Poisson, C.; Monteil, A.J.-C. (Akzo Nobel N.V.); 4-[4- or 6-(Trifluoromethyl-2-pyridinyl)]-1-piperazinyl-alkyl substd. lactams. EP 0482696; JP 1992282379; US 5180726 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	27397	2-Pyrrolidinone	616-45-5	C₄H₇NO	详情	详情
(II)	11883	1,4-Dibromobutane; 1,4-Butylene bromide	110-52-1	C₄H₈Br₂	详情	详情
(III)	59111	1-(4-bromobutyl)-2-pyrrolidinone		C₈H₁₄BrNO	详情	详情
(IV)	59112	1-[4-(trifluoromethyl)-2-pyridinyl]piperazine		C₁₀H₁₂F₃N₃	详情	详情

Extended Information