methyl (1S,2R)-2-[(1-adamantylamino)methyl]-1-phenylcyclopropanecarboxylate -Drug Synthesis Database

【结构式】

【分子编号】59010

【品名】methyl (1S,2R)-2-[(1-adamantylamino)methyl]-1-phenylcyclopropanecarboxylate

【CA登记号】

【分子式】C₂₂H₂₉NO₂

【分子量】339.4778

【元素组成】C 77.84% H 8.61% N 4.13% O 9.43%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

In a closely related method, bromo-ester (I) is condensed with 1-adamantanamine (II) in hot DMF to afford amino ester (III). The secondary amine of (III) is then alkylated with iodomethane to produce the title compound.

参考文献中间体

合成目标

【1】 Marrazzo, A.; et al.; Synthesis of (+)- and (-)-cis-2-[(1-adamantylamino)-methyl]-1-phenylcyclopropane derivatives as high affinity probes for sigma1 and sigma2 binding sites. Farmaco 2002, 57, 1, 45.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	59007	methyl (1S,2R)-2-(bromomethyl)-1-phenylcyclopropanecarboxylate		C₁₂H₁₃BrO₂	详情	详情
(II)	53978	1-Adamantanamine; 1-Adamantylamine; 1-Aminoadamantane	768-94-5	C₁₀H₁₇N	详情	详情
(III)	59010	methyl (1S,2R)-2-[(1-adamantylamino)methyl]-1-phenylcyclopropanecarboxylate		C₂₂H₂₉NO₂	详情	详情

Extended Information