diethyl (2S)-2-[(4-{1-[(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)methyl]propyl}benzoyl)amino]pentanedioate -Drug Synthesis Database

【结构式】

【分子编号】58989

【品名】diethyl (2S)-2-[(4-{1-[(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)methyl]propyl}benzoyl)amino]pentanedioate

【CA登记号】

【分子式】C₂₆H₃₃N₅O₆

【分子量】511.57812

【元素组成】C 61.04% H 6.5% N 13.69% O 18.76%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIII)

Condensation of the mixed anhydride (XI) with diethyl L-glutamate (XII) produces amide (XIII). The ethyl ester groups of (XIII) are finally hydrolyzed by means of NaOH to provide the title compound.

参考文献中间体

合成目标

【1】 Mcguire, J.J.; Zeng, Y.; Gangjee, A.; Kisliuk, R.L.; Synthesis of N-[4-[ethyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid as an antifolate. J Med Chem 2002, 45, 9, 1942.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(XI)	58987		C₂₂H₂₆N₄O₅	详情	详情
(XII)	11013	diethyl (2S)-2-aminopentanedioate	C₉H₁₇NO₄	详情	详情
(XIII)	58989	diethyl (2S)-2-[(4-{1-[(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)methyl]propyl}benzoyl)amino]pentanedioate	C₂₆H₃₃N₅O₆	详情	详情

Extended Information