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【结 构 式】 
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【分子编号】58979 【品名】 【CA登记号】 |
【 分 子 式 】C7H13N4NaO4 【 分 子 量 】240.194548 【元素组成】C 35% H 5.46% N 23.33% Na 9.57% O 26.64% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)Reaction of piperazine-1-carboxylic acid ethyl ester (I) with nitric oxide in the presence of NaOMe in a pressure bottle gives rise to the sodium piperazinyldiazenium diolate (II). This is finally condensed with 2,4-dinitrofluorobenzene (III) to produce the title compound.
| 【1】 Saavedra, J.E.; et al.; The secondary amine/nitric oxide complex ion R2N[N(O)NO](-) as nucleophile and leaving group in S(N)Ar reactions. J Org Chem 2001, 66, 9, 3090. |
| 【2】 Keefer, L.K.; Saavedra, J.E.; Srinivasan, A.; Rice, W.G.; Bogdan, C.; Ji, X. (US Department of Health & Human Services); O2-Arylated or O2-glycosylated 1-substd. diazen-1-ium-1,2-diolates and O2-substd. 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates. JP 2002506421; WO 9813358 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 24694 | N-ethoxycarbonylpiperidine; Ethyl 1-piperazinecarboxylate; N-Ethoxycarbonyl piperazine; N-Carbethoxy piperazine | 120-43-4 | C7H14N2O2 | 详情 | 详情 |
| (II) | 58979 | C7H13N4NaO4 | 详情 | 详情 | ||
| (III) | 58980 | 1-Fluoro-2,4-dinitrobenzene; Sanger's reagent; 2,4-Dinitro-1-fluorobenzene; 2,4-Dinitrofluorobenzene | 70-34-8 | C6H3FN2O4 | 详情 | 详情 |
Extended Information