|
【结 构 式】 
|
【分子编号】58859 【品名】2-[(2,5,9-trimethyl-7-oxo-7H-furo[3,2-g]chromen-3-yl)methoxy]ethyl methanesulfonate 【CA登记号】 |
【 分 子 式 】C18H20O7S 【 分 子 量 】380.4186 【元素组成】C 56.83% H 5.3% O 29.44% S 8.43% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)A different method starts with the chloromethylation of trimethyl psoralen (I) to afford (II). Subsequent condensation of chloride (II) with ethylene glycol (III) yields the hydroxyethoxy derivative (IV). This is converted to mesylate (V) upon treatment with methanesulfonyl chloride and triethylamine. Mesylate displacement by NaN3 leads to azide (VI). Finally, azide reduction to the target amine is accomplished by treatment with triphenylphosphine in moist THF.
| 【1】 Wollowitz, S.; Isaacs, S.T.; Rapoport, H.; Spielmann, H.P. (Steritech, Inc.); Cpds. for the photodecontamination of pathogens in blood. US 5399719; WO 9500141 . |
| 【2】 Wollowitz, S.; Isaacs, S.T.; Rapoport, H.; Spielman, H.P.; Niero, A. (Steritech, Inc.); Cpds. for the photodecontamination of pathogens in blood. WO 9614739 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 58856 | 2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one | C14H12O3 | 详情 | 详情 | |
| (II) | 58857 | 3-(chloromethyl)-2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one | C15H13ClO3 | 详情 | 详情 | |
| (III) | 11295 | Polyethylene glycol;1,2-Ethanediol;Monoethylene glycol; Ethylene glycol | 107-21-1 | C2H6O2 | 详情 | 详情 |
| (IV) | 58858 | 3-[(2-hydroxyethoxy)methyl]-2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one | C17H18O5 | 详情 | 详情 | |
| (V) | 58859 | 2-[(2,5,9-trimethyl-7-oxo-7H-furo[3,2-g]chromen-3-yl)methoxy]ethyl methanesulfonate | C18H20O7S | 详情 | 详情 | |
| (VI) | 58860 | 3-[(2-azidoethoxy)methyl]-2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one | C17H17N3O4 | 详情 | 详情 |
Extended Information