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【结 构 式】 
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【分子编号】58779 【品名】N-(4-aminophenyl)-1,2,3-thiadiazole-4-carboxamide 【CA登记号】 |
【 分 子 式 】C9H8N4OS 【 分 子 量 】220.25488 【元素组成】C 49.08% H 3.66% N 25.44% O 7.26% S 14.56% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)The mono-Boc-protected 1,4-phenylenediamine (I) was acylated with 1,2,3-thiadiazole-4-carbonyl chloride (II) to produce amide (III). After Boc group cleavage in (III) by means of trifluoroacetic acid, the resultant amine (IV) was condensed with 3,5-bis(trifluoromethyl)phenyl isothiocyanate (V) to afford the title thiourea.
| 【1】 Feld, B.; Bloom, J.; Norton, E.; Dushin, R.; Di Grandi, M.J.; Curran, K.; Jones, T.; Potent novel thioureas as inhibitors of human cytomegalovirus. 40th Intersci Conf Antimicrob Agents Chemother (Sept 17 2000, Toronto) 2001, Abst 1895. |
| 【2】 Bloom, J.D.; Ross, A.A.; O'Hara, B.M.; Curran, K.J.; DiGrandi, M.J.; Dushin, R.G.; Lang, S.A.; Norton, E.B. (Wyeth); Thiourea inhibitors of herpes viruses. EP 1137632; JP 2002531545; WO 0034238 . |
| 【3】 Jones, T.R.; Bloom, J.D.; Ross, A.A.; O'Hara, B.M.; Curran, K.J.; DiGrandi, M.J.; Dushin, R.G.; Lang, S.A.; Terefenko, E.A. (Wyeth); Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing a substd. phenylenediamine group. JP 2002533301; US 6166028; WO 0034261 . |
| 【4】 Bloom, J.D.; O'Hara, B.M.; DiGrandi, M.J.; Dushin, R.G.; Lang, S.A. (Wyeth); Thiourea inhibitors of herpes viruses. EP 1137647; JP 2002531557; WO 0034268 . |
| 【5】 Bloom, J.D.; Ross, A.A.; O'Hara, B.M.; Curran, K.J.; DiGrandi, M.J.; Dushin, R.G.; Lang, S.A.; Norton, E.B. (Wyeth); alpha-Methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group. JP 2002531555; WO 0034260 . |
| 【6】 Jones, T.R.; Bloom, J.D.; Ross, A.A.; O'Hara, B.M.; Curran, K.J.; DiGrandi, M.J.; Dushin, R.G.; Lang, S.A.; Terefenko, E.A. (Wyeth); Heterocyclic carboxamide-containing thiourea inhibitors of herpes viruses containing phenylenediamine group. JP 2002531554; WO 0034258 . |
| 【7】 Bloom, J.D.; O'Hara, B.M.; DiGrandi, M.J.; Dushin, R.G.; Lang, S.A. (Wyeth); Thiourea inhibitors of herpes viruses. EP 1140913; JP 2002531558; WO 0034269 . |
| 【8】 Bloom, J.D.; O'Hara, B.M.; DiGrandi, M.J.; Dushin, R.G.; Lang, S.A. (Wyeth); Acetamide and substd. acetamide-containing thiourea inhibitors of herpes viruses. JP 2002531544; WO 0034237 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 43972 | 4-(N-Boc-aminomethyl)aniline;tert-butyl (4-aminophenyl)carbamate;tert-butyl 4-aminophenylcarbamate | C11H16N2O2 | 详情 | 详情 | |
| (II) | 58777 | 1,2,3-thiadiazole-4-carbonyl chloride | C3HClN2OS | 详情 | 详情 | |
| (III) | 58778 | tert-butyl 4-[(1,2,3-thiadiazol-4-ylcarbonyl)amino]phenylcarbamate | C14H16N4O3S | 详情 | 详情 | |
| (IV) | 58779 | N-(4-aminophenyl)-1,2,3-thiadiazole-4-carboxamide | C9H8N4OS | 详情 | 详情 | |
| (V) | 58780 | 3,5-Bis(trifluoromethyl)phenyl isothiocyanate | 23165-29-9 | C9H3F6NS | 详情 | 详情 |
Extended Information