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【结 构 式】

【分子编号】58660

【品名】tert-butyl 3-(2-amino-2-oxoethanimidoyl)-1,2,4-thiadiazol-5-ylcarbamate

【CA登记号】

【 分 子 式 】C11H17N5O4S

【 分 子 量 】315.35328

【元素组成】C 41.9% H 5.43% N 22.21% O 20.29% S 10.17%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

The condensation of the aminocephem derivative (I) with the ethoxyiminoacetic acid (II) by means of POCl3 and NMM gives the corresponding amide (III), which is condensed with the imidazo pyridine (IV) by means of NaI or NaBr to yield the protected imidazopyridinium salt (V). Finally, this compound is deprotected by means of AlCl3 and anisole, TiCl4 and anisole or sulfuric and formic acids to afford the target cephem-carboxylate derivative.

1 Itani, H.; Ishikura, K.; Yoshizawa, H.; et al.; S-3578, a new broad spectrum parenteral cephalosporin exhibiting potent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa synthesis and structure-activity relationships. J Antibiot 2002, 55, 11, 975.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 21627 4-methoxybenzyl (7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate C16H17ClN2O4S 详情 详情
(II) 58660 tert-butyl 3-(2-amino-2-oxoethanimidoyl)-1,2,4-thiadiazol-5-ylcarbamate C11H17N5O4S 详情 详情
(III) 54821 4-methoxybenzyl (7R)-7-{[2-{5-[(tert-butoxycarbonyl)amino]-1,2,4-thiadiazol-3-yl}-2-(ethoxyimino)acetyl]amino}-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate C27H31ClN6O8S2 详情 详情
(IV) 54814 tert-butyl 3-(1H-imidazo[4,5-b]pyridin-1-yl)propyl(methyl)carbamate C15H22N4O2 详情 详情
(V) 54822 4-[((7R)-7-{[2-{5-[(tert-butoxycarbonyl)amino]-1,2,4-thiadiazol-3-yl}-2-(ethoxyimino)acetyl]amino}-2-{[(4-methoxybenzyl)oxy]carbonyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl]-1-{3-[(tert-butoxycarbonyl)(methyl)amino]propyl}-1H-imidazo[4,5-b]pyridin-4-ium C42H53N10O10S2 详情 详情
Extended Information