(4aS,6R,8aS)-3-methoxy-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol -Drug Synthesis Database

【结构式】

【分子编号】58654

【品名】(4aS,6R,8aS)-3-methoxy-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol

【CA登记号】

【分子式】C₁₆H₁₉NO₃

【分子量】273.3318

【元素组成】C 70.31% H 7.01% N 5.12% O 17.56%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The N-demethylation of galantamine (I) by means of MCPBA and FeSO4 in dichloromethane gives the N-demethylated compound (II), which is then remethylated with 14C-methyl iodide and diisopropylamine (DIA) in methanol to obtain the target labeled compound.

参考文献中间体

合成目标

【1】 Janssen, C.G.M.; et al.; Synthesis of 3H-, 14C-, and stable-isotope-labelled galantamine. J Label Compd Radiopharm 2002, 45, 10, 841.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	41226	(4aS,6R,8aS)-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol	357-70-0	C₁₇H₂₁NO₃	详情	详情
(II)	58654	(4aS,6R,8aS)-3-methoxy-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol		C₁₆H₁₉NO₃	详情	详情

Extended Information