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【结 构 式】 
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【分子编号】58649 【品名】 【CA登记号】 |
【 分 子 式 】C40H42N4O10S 【 分 子 量 】770.86044 【元素组成】C 62.33% H 5.49% N 7.27% O 20.76% S 4.16% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(LIII)The Pictet-Spengler cyclization of (LI) with 2-(3-hydroxy-4-methoxyphenyl)ethylamine (LII) by means of NaOAc in ethanol yields the spiro-tetrahydroisoquinoline (LIII). Finally, the nitrile group of (LIII) is treated with AgNO3 in acetonitrile/water to afford the target Ecteinascidin 743.
| 【1】 Abe, M.; Yanagisawa, A.; Tohma, S.; Kan, T.; Fukuyama, T.; Endo, A.; Total synthesis of ecteinascidin 743. J Am Chem Soc 2002, 124, 23, 6552. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (LI) | 58648 | (1R,2R,3R,11S,12R,14R)-12-cyano-5-hydroxy-6-methoxy-7,21,30-trimethyl-26,27-dioxo-17,19,28-trioxa-24-thia-13,30-diazaheptacyclo[12.9.6.1~3,11~.0~2,13~.0~4,9~.0~15,23~.0~16,20~]triaconta-4,6,8,15,20,22-hexaen-22-yl acetate | C31H31N3O9S | 详情 | 详情 | |
| (LII) | 36471 | 5-(2-aminoethyl)-2-methoxyphenol | C9H13NO2 | 详情 | 详情 | |
| (LIII) | 58649 | C40H42N4O10S | 详情 | 详情 |
Extended Information