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【结 构 式】 
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【分子编号】58600 【品名】N-[(1R)-1-methyl-2-phenylethyl]-2-propyn-1-amine; N-[(1R)-1-methyl-2-phenylethyl]-N-(2-propynyl)amine 【CA登记号】 |
【 分 子 式 】C12H15N 【 分 子 量 】173.25784 【元素组成】C 83.19% H 8.73% N 8.08% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)The reduction of 11C-CO2 (I) by means of LiAlH4 in THF gives 11C-methanol (II), which is treated with 57 % IH to yield 11C-methyl iodide (III). The reaction of (III) with silver triflate affords 11C-methyl triflate (IV). Finally, (R)(-)-nor-selegiline (nor-deprenil) (V) is methylated with the radiolabeled methyl triflate (IV) by means of NaOH in aqueous acetone to obtain the target radiolabeled compound.
| 【1】 Dolle, F.; et al.; Efficient synthesis and formulation of (R)-(-)-[11C]deprenyl, a selective radioligand for the quantification of MAO-B activity using PET. J Label Compd Radiopharm 2002, 45, 10, 803. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (II) | 58598 | methanol | CH4O | 详情 | 详情 | |
| (III) | 58599 | iodomethane | CH3I | 详情 | 详情 | |
| (IV) | 17414 | methyl trifluoromethane sulfonate; methyl trifluoromethanesulfonate | 333-27-7 | C2H3F3O3S | 详情 | 详情 |
| (IV) | 45233 | methyl trifluoromethanesulfonate | C2H3F3O3S | 详情 | 详情 | |
| (V) | 58600 | N-[(1R)-1-methyl-2-phenylethyl]-2-propyn-1-amine; N-[(1R)-1-methyl-2-phenylethyl]-N-(2-propynyl)amine | C12H15N | 详情 | 详情 |
Extended Information