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【结 构 式】 
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【分子编号】58577 【品名】(2S)-2-({[6-({[(1S)-2-hydroxy-1-(1H-imidazol-5-ylmethyl)-2-oxoethyl]amino}carbonyl)-2-pyridinyl]carbonyl}amino)-3-(1H-imidazol-5-yl)propanoic acid 【CA登记号】 |
【 分 子 式 】C19H19N7O6 【 分 子 量 】441.40344 【元素组成】C 51.7% H 4.34% N 22.21% O 21.75% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)In an alternative process, acid chloride (III) was condensed with histidine (IV) in the presence of KOH in H2O/THF producing de diamide diacid (V), which was then esterified by treatment with SOCl2 in cold methanol.
| 【1】 You, J.; et al.; Synthesis of new chiral macrocyclic tetraoxo polyamines containing pyridine ring and functional arms. Synth Commun 1999, 29, 14, 2447. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (III) | 58575 | Pyridine-2,6-dicarbonyl chloride; Pyridine-2,6-dicarboxylic acid chloride; 2,6-Pyridinedicarbonyl dichloride; 2,6-Pyridinedicarboxylic acid chloride | 3739-94-4 | C7H3Cl2NO2 | 详情 | 详情 |
| (IV) | 58576 | (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid | C6H9N3O2 | 详情 | 详情 | |
| (V) | 58577 | (2S)-2-({[6-({[(1S)-2-hydroxy-1-(1H-imidazol-5-ylmethyl)-2-oxoethyl]amino}carbonyl)-2-pyridinyl]carbonyl}amino)-3-(1H-imidazol-5-yl)propanoic acid | C19H19N7O6 | 详情 | 详情 |
Extended Information