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【结 构 式】 
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【分子编号】58540 【品名】methyl (E)-3-(6-{[(4-chlorophenyl)sulfonyl]amino}-2-methyl-5,6,7,8-tetrahydro-1-naphthalenyl)-2-propenoate 【CA登记号】 |
【 分 子 式 】C21H22ClNO4S 【 分 子 量 】419.92872 【元素组成】C 60.07% H 5.28% Cl 8.44% N 3.34% O 15.24% S 7.64% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIV)Wittig condensation of aldehyde (XIII) with (methoxycarbonylmethylene)triphenylphosphorane gave the conjugated ester (XIV). This was further reduced to the saturated ester (XV) by using either samarium iodide or sodium borohydride/cobaltous chloride. Finally, saponification of the methyl ester function of (XV) afforded the title sodium carboxylate salt.
| 【1】 Cimetière, B.; Dubuffet, T.; Muller, O.; Descombes, J.-J.; Simonet, S.; Verbeuren, T.J.; Laubie, M.; Lavielle, G.; Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists. Bioorg Med Chem Lett 1998, 8, 11, 1375. |
| 【2】 Lavielle, G.; Dubuffet, T.; Muller, O.; Laubie, M.; Verbeuren, T.; Simonet, S.; Descombes, J.-J. (ADIR et Cie.); 1,2,3,4-Tetrahydronaphthalene, chroman and thiochroman derivs. as antithrombotic agents. CA 2118102; EP 0648741; FR 2711139; JP 1995188155 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XIII) | 58539 | 4-chloro-N-(5-formyl-6-methyl-1,2,3,4-tetrahydro-2-naphthalenyl)benzenesulfonamide | C18H18ClNO3S | 详情 | 详情 | |
| (XIV) | 58540 | methyl (E)-3-(6-{[(4-chlorophenyl)sulfonyl]amino}-2-methyl-5,6,7,8-tetrahydro-1-naphthalenyl)-2-propenoate | C21H22ClNO4S | 详情 | 详情 | |
| (XV) | 58541 | methyl 3-(6-{[(4-chlorophenyl)sulfonyl]amino}-2-methyl-5,6,7,8-tetrahydro-1-naphthalenyl)propanoate | C21H24ClNO4S | 详情 | 详情 |
Extended Information