ethyl 2-[5-(1H-imidazol-1-yl)-2-nitroanilino]acetate -Drug Synthesis Database

【结构式】

【分子编号】58533

【品名】ethyl 2-[5-(1H-imidazol-1-yl)-2-nitroanilino]acetate

【CA登记号】

【分子式】C₁₃H₁₄N₄O₄

【分子量】290.27872

【元素组成】C 53.79% H 4.86% N 19.3% O 22.05%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IX)

In a related procedure, the nitrophenyl imidazole (IX) was reduced to diamine (X) by catalytic hydrogenation. Acylation of diamine (X) with ethyl chloroglyoxylate, followed by ring closure, gave rise to quinoxaline (XI), which was then nitrated to afford (VIII) with fuming nitric acid. Finally, basic hydrolysis of the ethyl ester group of (VIII) as above, yielded the corresponding acid.

参考文献中间体

合成目标

【1】 Shishikura, J.; Inami, H.; Sakamoto, S.; Tsukamoto, S.; Sasamata, M.; Okada, M.; Fujii, M. (Yamanouchi Pharmaceutical Co., Ltd.); 1,2,3,4-Tetrahydroquinoxalindione deriv.. EP 0784054; US 6096743; WO 9610023 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(IX)	58533	ethyl 2-[5-(1H-imidazol-1-yl)-2-nitroanilino]acetate	C₁₃H₁₄N₄O₄	详情	详情
(X)	58534	ethyl 2-[2-amino-5-(1H-imidazol-1-yl)anilino]acetate	C₁₃H₁₆N₄O₂	详情	详情
(XI)	58535	ethyl 2-[7-(1H-imidazol-1-yl)-2,3-dioxo-3,4-dihydro-1(2H)-quinoxalinyl]acetate	C₁₅H₁₄N₄O₄	详情	详情
(XII)	58532	ethyl 2-[7-(1H-imidazol-1-yl)-6-nitro-2,3-dioxo-3,4-dihydro-1(2H)-quinoxalinyl]acetate	C₁₅H₁₃N₅O₆	详情	详情

Extended Information