【结 构 式】 |
【分子编号】58505 【品名】2-[(4-aminobutyl)amino]acetic acid 【CA登记号】 |
【 分 子 式 】C6H14N2O2 【 分 子 量 】146.18944 【元素组成】C 49.3% H 9.65% N 19.16% O 21.89% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)Reductive condensation of 1,4-butanediamine (I) with glyoxylic acid (II) affords 3,8-diazaoctanoic acid (III). Subsequent acylation of diamino acid (III) with 2,3-diacetoxybenzoyl chloride (IV) provides diamide (V). After activation of (V) as the corresponding mixed anhydride with either methyl or isobutyl chloroformate, condensation with ampicillin (VI) yields the title compound.
【1】 RF-2691A. Drug Data Rep 1995, 17, 9, 867. |
【2】 Berg, A.; Heinisch, L.; Mollmann, U.; Wittmann, S.; Scherlitz-Hofmann, I.; Stoiber, T. (Grunenthal GmbH); Catecholate beta-lactam conjugates, method for producing the same and the use thereof. DE 10111160; WO 0270016 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 42070 | 1,4-butanediamine; 4-aminobutylamine | 110-60-1 | C4H12N2 | 详情 | 详情 |
(II) | 15618 | 2-Oxoacetic acid; Glyoxylic Acid | 298-12-4 | C2H2O3 | 详情 | 详情 |
(III) | 58505 | 2-[(4-aminobutyl)amino]acetic acid | C6H14N2O2 | 详情 | 详情 | |
(IV) | 58506 | 2-(acetyloxy)-3-(chlorocarbonyl)phenyl acetate | C11H9ClO5 | 详情 | 详情 | |
(V) | 58507 | 2-[[2,3-bis(acetyloxy)benzoyl](4-{[2,3-bis(acetyloxy)benzoyl]amino}butyl)amino]acetic acid | C28H30N2O12 | 详情 | 详情 | |
(VI) | 31107 | (2S,5R,6R)-6-[[(2R)-2-amino-2-phenylethanoyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid | 69-53-4 | C16H19N3O4S | 详情 | 详情 |
Extended Information