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【结 构 式】

【分子编号】58505

【品名】2-[(4-aminobutyl)amino]acetic acid

【CA登记号】

【 分 子 式 】C6H14N2O2

【 分 子 量 】146.18944

【元素组成】C 49.3% H 9.65% N 19.16% O 21.89%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Reductive condensation of 1,4-butanediamine (I) with glyoxylic acid (II) affords 3,8-diazaoctanoic acid (III). Subsequent acylation of diamino acid (III) with 2,3-diacetoxybenzoyl chloride (IV) provides diamide (V). After activation of (V) as the corresponding mixed anhydride with either methyl or isobutyl chloroformate, condensation with ampicillin (VI) yields the title compound.

1 RF-2691A. Drug Data Rep 1995, 17, 9, 867.
2 Berg, A.; Heinisch, L.; Mollmann, U.; Wittmann, S.; Scherlitz-Hofmann, I.; Stoiber, T. (Grunenthal GmbH); Catecholate beta-lactam conjugates, method for producing the same and the use thereof. DE 10111160; WO 0270016 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 42070 1,4-butanediamine; 4-aminobutylamine 110-60-1 C4H12N2 详情 详情
(II) 15618 2-Oxoacetic acid; Glyoxylic Acid 298-12-4 C2H2O3 详情 详情
(III) 58505 2-[(4-aminobutyl)amino]acetic acid C6H14N2O2 详情 详情
(IV) 58506 2-(acetyloxy)-3-(chlorocarbonyl)phenyl acetate C11H9ClO5 详情 详情
(V) 58507 2-[[2,3-bis(acetyloxy)benzoyl](4-{[2,3-bis(acetyloxy)benzoyl]amino}butyl)amino]acetic acid C28H30N2O12 详情 详情
(VI) 31107 (2S,5R,6R)-6-[[(2R)-2-amino-2-phenylethanoyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 69-53-4 C16H19N3O4S 详情 详情
Extended Information