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【结 构 式】 
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【分子编号】58442 【品名】2-chloro-4-nitrophenyl 1-methyl-1H-imidazol-2-yl sulfide; 2-[(2-chloro-4-nitrophenyl)sulfanyl]-1-methyl-1H-imidazole 【CA登记号】 |
【 分 子 式 】C10H8ClN3O2S 【 分 子 量 】269.71124 【元素组成】C 44.53% H 2.99% Cl 13.14% N 15.58% O 11.86% S 11.89% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Condensation of 3-chloro-4-fluoronitrobenzene (I) with the sodium derivative of 2-mercapto-1-methylimidazole (II) affords the diaryl sulfide (III). Subsequent nitro group reduction in (III) using iron dust and ammonium chloride provides the intermediate aniline (IV).
| 【1】 Dutia, M.; Powell, D.W.; Berger, D.M.; et al.; Synthesis and evaluation of 4-anilino substituted 3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade. 224th ACS Natl Meet (Aug 18 2002, Boston) 2002, Abst MEDI 105. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 58441 | 2-chloro-1-fluoro-4-nitrobenzene; 3-Chloro-4-fluoronitrobenzene; 4-Fluoro-3-chloronitrobenzene | 350-30-1 | C6H3ClFNO2 | 详情 | 详情 |
| (II) | 18783 | 1-methyl-1H-imidazol-2-ylhydrosulfide; 1-methyl-1H-imidazole-2-thiol | 60-56-0 | C4H6N2S | 详情 | 详情 |
| (III) | 58442 | 2-chloro-4-nitrophenyl 1-methyl-1H-imidazol-2-yl sulfide; 2-[(2-chloro-4-nitrophenyl)sulfanyl]-1-methyl-1H-imidazole | C10H8ClN3O2S | 详情 | 详情 | |
| (IV) | 58443 | 3-chloro-4-[(1-methyl-1H-imidazol-2-yl)sulfanyl]aniline; 3-chloro-4-[(1-methyl-1H-imidazol-2-yl)sulfanyl]phenylamine | C10H10ClN3S | 详情 | 详情 |
Extended Information