【结 构 式】 |
【分子编号】58440 【品名】methyl (2S)-2-[((2S)-2-{[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]amino}propanoyl)amino]-5-phenylpentanoate 【CA登记号】 |
【 分 子 式 】C23H26F2N2O5 【 分 子 量 】448.4667264 【元素组成】C 61.6% H 5.84% F 8.47% N 6.25% O 17.84% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(VI)Coupling between methyl 2-amino-5-phenylpentanoate (I) and N-Boc-alanine (II) affords dipeptide (III). Deprotection of (III) with trifluoroacetic acid yields amine (IV), which is then acylated with (S)-3,5-difluoromandelic acid (V), producing amide (VI). Finally, ester group reduction using LiBH4 leads to the desired alcohol.
【1】 Garofalo, A.W.; et al.; A series of C-terminal amino alcohol dipeptide Abeta inhibitors. 28th Natl Med Chem Symp (June 8 2002, San Diego) 2002, Abst 11. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 58436 | methyl (2S)-2-amino-5-phenylpentanoate | C12H17NO2 | 详情 | 详情 | |
(II) | 26450 | Boc-L-Alanine;(S)-2-((tert-butoxycarbonyl)amino)propanoic acid;N-Boc-L-alanine; (2S)-2-[(tert-butoxycarbonyl)amino]propionic acid | 15761-38-3 | C8H15NO4 | 详情 | 详情 |
(III) | 58437 | methyl (2S)-2-({(2S)-2-[(tert-butoxycarbonyl)amino]propanoyl}amino)-5-phenylpentanoate | C20H30N2O5 | 详情 | 详情 | |
(IV) | 58438 | methyl (2S)-2-{[(2S)-2-aminopropanoyl]amino}-5-phenylpentanoate | C15H22N2O3 | 详情 | 详情 | |
(V) | 58439 | (2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoic acid | C8H6F2O3 | 详情 | 详情 | |
(VI) | 58440 | methyl (2S)-2-[((2S)-2-{[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]amino}propanoyl)amino]-5-phenylpentanoate | C23H26F2N2O5 | 详情 | 详情 |
Extended Information